ATP-Pro® (U.S. formulation)
Patents / References
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Intellectual Property
The D-Ribose used in the Eniva ATP-Pro® product has been granted patent protection covering a broad range of nutritional and pharmaceutical uses for ribose. These include such things as a) use of ribose in cardiac diagnosis, b) energy enhancement, c) use for the prevention of muscle soreness, stiffness and cramping, d) use to treat ischemic tissue, and e) use to treat fibromyalgia.*
U.S. patent number 6,159,942 covers the oral use of ribose as an energy enhancing supplement when taken alone or in combination with other ingredients in drinks, energy bars, dietary supplements or other food and nutrition products.
U.S. patent number 6,159,943 covers the use of ribose for the prevention of muscle soreness and cramping following muscle over work or in cases of restricted circulation.
U.S. patents 4,719,201 and 4,605,644 cover the use of ribose alone or in combination with adenine for treating ischemic tissue.
U.S. patents and cover the use of ribose to unmask hibernating myocardium and aid in perfusion imaging diagnosis, respectively.
Three patent applications, including use of ribose in treatment of fibromyalgia, have been allowed in the United Kingdom and several are filed internationally under the Patent Cooperation Treaty designating all treaty countries.
Several additional patents are pending. When all pending patents are issued, Bioenergy will have exclusive rights to the use of ribose across a broad range of nutritional and medical applications.
Using ribose for uses covered by these patents, except under license, is considered patent infringement and is subject to prosecution.
Scientific References
1. Andreoli S. Mechanisms of Endothelial Cell ATP Depletion after Oxidant Injury. Pediatric Res. 1989; 25(1): 97-100
2. Angello D, Wilson R, Gee D, Perlmutter N. Recovery of Myocardial Function and Thallium 201 Redistribution Using Ribose. Am J Card Imag. 1989; 3(4): 256-265.
3. Asimakis G, Zwischenberger J, Inners-McBride K, Sordahl L, Conti V. Postischemic Recovery of Mitochondrial Adenine Nucleotides in the Heart. Circ. 1992; 85(6): 2212-2220.
4. Baldwin D, McFalls E, Jaimes D, Fashingbauer P, Nemzek T, Ward H. Myocardial Glucose Metabolism and ATP Levels are Decreased Two Days after Global Ischemia. J Surg Res. 1996; 63: 35-38.
5. Chatham J, Challiss R, Radda G, Seymour A. Studies of the Protective Effect of Ribose in Myocardial Ischaemia by using 31P-Nuclear Magnetic Resonance Spectroscopy. Biochem Soc Proc. 1985; 13: 885-88.
6. Clay MA, Stewart-Richardson P, Tasset D, Williams J. Chronic Alcoholic Cardiomyopathy: Protection of the Isolated Ischemic Working Heart by Ribose. Biochem Internat. 1988; 17(5): 791-800.
7. Cohen M, Charney R, Hershman R, Fuster V, Gorlin R, Francis X. Reversal of Chronic Ischemic Myocardial Dysfunction After Transluminal Coronary Angioplasty. JACC. 1988; 12(5): 1193-1198.
8. Dow J, Nigdikar S, Bowditch J. Adenine Nucleotide Synthesis de novo in Mature Rat Cardiac Myocytes. Biochim Biophys Acta. 1985; 847(2): 223-227.
9. Einzig S, St.Cyr J., Bianco R, Schneider J. Lorenz E, Foker J. Myocardial ATP Repletion with Ribose Infusion. Pediatr Res. 1985; 19: 127A.
10. Einzig S, St. Cyr J, Schneider J, Bianco R, Foker J. Maintained Myocardial ATP with Long Term Ribose. Pediatr Res. 1986; 20(4 pt 2): 169A.
11. Gao W, Liu Y, Marban E. Selective Effects of Oxygen Free Radicals on Excitation-Contraction Coupling in Ventricular Muscle. Circ. 1996; 94: 2597-2604.
12. Geisbuhler T, Schwager T. Ribose-Enhanced Synthesis of UTP, CTP, and GTP From Parent Nucleosides in Cardiac Myocytes. J Mol Cell Cardiol. 1998; 30(4): 879-887.
13. Goncalves RP, GC Bennet, CP Leblond. Fate of 3H-ribose in the rat as detected by autoradiography. Anat Rec 165:543-557, 1969.
14. Gradus-Pizlo I, SG Sawada, S Lewis, S Khouri, DS Segar, R Kovacs, H Feigenbaum. Effect of D-ribose on the detection of the hibernating myocardium during the low dose dobutamine stress echocardiography. Circ 100(18):3394, 1999.
15. Gross M, S Reiter, N Zollner. Metabolism of D-ribose administered to healthy persons and to patients with myoadenylate deaminase deficiency. Klin Wochenschr 67:1205-1213, 1989.
16. Gross G, Auchampac J, Role of ATP Dependent Potassium Channels in Myocardial Ischaemia. Cardiovasc Res. 1992; 26: 1011-1016.
17. Haas G, DeBoer L, O'Keefe E, Bodenhamer R, Geffin G, Drop L, Teplick R, Daggett W. Reduction of postischemic myocardial dysfunction by substrate repletion during reperfusion. Circ. 1984; 70: 165-174.
18. Hegewald MG, RT Palac, D Angello, NS Perlmutter, RA Wilson. Ribose infusion accelerates thallium redistribution with early imaging compared with late 24-hour imaging without ribose. JACC 18:1671-1681, 1991.
19. Ibel H, Zimmer HG. Metabolic Recovery Following Temporary Regional Myocardial Ischemia in the Rat. J Mo. Cell Cardiol. 1986; 18(Suppl 4), 61-65.
20. Illien S, Omran H, MacCarter D, St. Cyr J. Ribose Improves Myocardial Function in Congestive Heart Failure. FASEB J. 2001; 15(5): A1142.
21. Kalsi K, Smolenski R, Yacoub M. Effects of Nucleoside Transport Inhibitors and Adenine/Ribose Supply on ATP Concentration and Adenosine Production in Cardiac Myocytes. Moll. Cell. BiolChem. 1998; 180(1-2): 193-199.
22. Keith M. Increased Oxidative Stress in Patients with Congestive Heart Failure. J Am Coll Cardiol. 1998; 31(6): 1352-1356.
23. Koumi S, Martin R, Sato R. Alterations in ATP-Sensitive Potassium Channel Sensitivity to ATP in Failing Human Hearts. Am J Physiol. 1997; 272(41): H1656-H1665.
24. Lanoue K, Watts J, Koch C. Adenine Nucleotide Transport During Cardiac Ischemia. Am J Physiol. 1981; 24: H663-H671.
25. Lewandowski E, Yu X, LaNoue K, White L, Doumen C, O'Donnell M. Altered Metabolic Exchange Between Subcellular Compartments in Intact Postischemic Rabbit Hearts. Circ Res. 1997; 81: 165-175.
26. Lortet S, H-G Zimmer. Functional and metabolic effects of ribose in combination with prazosin, verapamil and metroprolol in rats in vivo. Cardiovasc Res 23:702-708, 1989.
27. Mahoney J, Sako E, Seymour K, Marquardt C, Foker J. A Comparison of different Carbohydrates as Substrates for the Isolated Working Heart. J Surg Res. 1989; 47: 530-534.
28. Mahoney J. Recovery of Postischemic Myocardial ATP Levels and Hexosemonophosphate Shunt Activity. Med Hypoth. 1990; 31: 21-23.
29. Mauser M, Hoffmeister H, Nienaber C, Schaper W. Influence of Ribose, Adenosine and "AICAR" on the Rate of Myocardial Adenosine Triphosphate Synthesis during Reperfusion after Coronary Artery Occlusion in the Dog. Circ Res. 1985; 56: 220-230.
30. Muller C, Zimmer H, Gross M, Gresser U, Brotsack I, Wehling M, Pliml W. Effect of Ribose on Cardiac Adenine Nucleotides in a Donor Model for Heart Transplantation. Eur J Med Res. Dec 1998; 554-558.
31. Omran H, Illien S, MacCarter D, St. Cyr J. Ribose Improves Myocardial Function and Quality of Life in Congestive Heart Failure Patients. J Mol Cell Cardiol. 2001; 33(6): A173.
32. Pasque M, Spray T, Peliom G, van Trigt P, Peyton R, Currie W, Wechsler A. Ribose-Enhanced Myocardial Recovery following Ischemia in the Isolated Working Rat Heart. J Thorac Cardiovasc Surg. 1982; 83(3): 390-398.
33. Pasque M, Wechsler A. Metabolic Intervention to Affect Myocardial Recovery Following Ischemia. Ann Surg. 1984; 200: 1-10.
34. Pauly D, Pepine C. D-Ribose as a Supplement for Cardiac Energy Metabolism. J Cardiovasc Pharmacol Ther. 2000; 5(4): 249-258.
35. Perlmutter NS, RA Wilson, DA Angello, RT Palac, J Lin, BG Brown. Ribose facilitates thallium-201 redistribution in patients with coronary artery disease. J Nucl Med 32:193-200, 1991.
36. Pliml W, von Arnim T, Stablein A, Hofmann H, Zimmer H, Erdmann E. Effects of Ribose on Exercise-Induced Ischaemia in Stable Coronary Artery Disease. Lancet. Aug 1992; 340: 507-510.
37. Pouleur H. Diastolic Dysfunction and Myocardial Energetics. Eur Heart J. 1990; 11(Supp C): 30-34.
38. Reibel D, Rovetto M. Myocardial ATP Synthesis and Mechanical Function Following Oxygen Deficiency. Am J Physiol. 1978; 234 (5): H620-H624.
39. Reimer K, Hill M, Jennings R. Prolonged Depletion of ATP and of the Adenine Nucleotide Pool due to Delayed Resynthesis of Adenine Nucleotides following Reversible Myocardial Ischemic Injury in Dogs. J Mol Cell Cardiol. 1981; 13: 229-239.
40. Sami H, Bittar N. The Effect of Ribose Administration on Contractile Recovery Following Brief Periods of Ischemia. Anesthesiol. 1987; 67(3A): A74.
41. Schneider J, St. Cyr J, Mahoney J, Bianco R, Ring W, Foker J. Recovery of ATP and Return of Function After Global Ischemia. Circ. 1985; 72(4 pt 2): III-298.
42. Segal S, J Foley. The metabolism of D-ribose in man. J Clin Invest, 719-735, 1958.
43. Seifert J, Subudhi A, Fu M-X, Riska K, John J. The Effects of Ribose Ingestion on Indicies of Free Radical Production During Hypoxic Exercise. Free Rad Biol Med. 2002; 33(suppl 1): S269.
44. Siess M, Delabar U, Seifart H. Cardiac Synthesis and Degradation of Pyridine Nucleotides and the Level of Energy-Rich Phosphates Influenced by Various Precursors. Adv Myocardiol. 1983; 4: 287-308.
45. Smolenski R, Kalsi K, Zych M, Kochan Z, Yacoub M. Effects of Adenine/Ribose Supply on Adenosine Production and ATP Concentration in Adenosine Kinase-Inhibited Cardiac Cells. Adv Exp Med Biol. 1998; 431: 385-388.
46. Smolenski R, Kalsi K, Zych M, Kochan Z, Yacoub M. Adenine/Ribose Supply Increases Adenosine Production and Protects ATP Pool in Adenosine Kinase-Inhibited Cardiac Cells. J Mol Cell Cardiol. 1998; 30(3): 673-683.
47. St. Cyr J, Bianco R, Foker J. Myocardial High-Energy Phosphate Levels in Cardiomyopathic Turkeys. J Surg Res. 1986; 41: 256-259.
48. St. Cyr J, Ward H, Kriett J, Alyono D, Einzig S, Bianco R, Anderson R, Foker J. Long-Term Model for Evaluation of Myocardial Metabolic Recovery Following Global Ischemia. Adv Exp Med Biol. 1986; 194: 401-441.
49. St. Cyr J, Bianco R, Schneider J Mahoney J, Tveter K, Einzig S, Foker J. Enhanced High Energy Phosphate Recovery with Ribose Infusion after Global Myocardial Ischemia in a Canine Model. J Surg Res. 1989; 46(2): 157-162.
50. Swain JL, Sabina R, McHale P, Greenfield J, Holmes E. Prolonged Myocardial Nucleotide Depletion after Brief Ischemia in the Open-Chest Dog. Am J Physiol. 1982; 242: H818-H826.
51. Taegtmeyer H, Roberts A, Raine A. Energy Metabolism in Reperfused Heart Muscle: Metabolic Correlates to Return of Function. JACC. 1985; 6(4): 864-870.
52. Taegtmeyer H, King L, Jones B. Energy Substrate Metabolism, Myocardial Ischemia and Targets for Pharmacotherapy. Am J Cardiol. 1998; 82(5A): 54K-60K.
53. Taegtmeyer H. Metabolism - The Lost Child of Cardiology. J Am Coll Cardiol. 2000; 36(4): 1386-1388.
54. Tan ZT. Ruthenium Red, Ribose and Adenine Enhance Recovery of Reperfused Rat Heart. Coronary Artery Dis. 1993; 4(3): 305-309.
55. Tveter K, St. Cyr J, Schneider J, Bianco R, Foker J. Enhanced Recovery of Diastolic Function After Global Myocardial Ischemia in the Intact Animal. Pediatr Res. 1988; 23: 226A.
56. Vance R, Einzig S, Kreisler K, St. Cyr J. D-Ribose Maintains Ejection Fraction Following Aortic Valve Surgery. FASEB J. 2000; 14(4): A419.
57. Ward H, St. Cyr J, Cogordan J, Alyono D, Bianco R, Kriett J, Foker J. Recovery of Adenine Nucleotide Levels After Global Myocardial ischemia in Dogs. Surgery. 1984; 96(2): 248-255.
58. Wyatt D, S Ely, R Lasley, R Walsh, R Mainwaring, R Berne, R Mentzer. Purine-enriched asanguineous cardioplegia retards adenosine triphosphate degradation during ischemia and improves postischemic ventricular function. J Thorac Cardiovsac Res 97:771-778, 1989.
59. Zimmer HG, Gerlach E. Stimulation of Myocardial Adenine Nucleotide Biosynthesis by Pentoses and Pentitols. Pflugers Arch. 1978; 376: 223-227.
60. Zimmer HG. Restitution of Myocardial Adenine Nucleotides: Acceleration by Administration of Ribose. J Physiol, Paris. 1980; 76: 769-775.
61. Zimmer HG, Ibel H, Stseinkopff G. Studies on the Hexose Monophosphate Shunt in the Myocardium during Development of Hypertrophy. Adv Myocardiol. 1980; 1: 487-492.
62. Zimmer H-G, H Ibel, G Steinkopff, G Korb. Reduction of the isoproterenol-induced alterations in cardiac adenine nucleotides and morphology by ribose. Science 207:319-321, 1980.
63. Zimmer H-G. Adenine nucleotide myocardial recovery following ischemia in the isolated working rat heart. J Thorac Cardiovasc Surg 83:390-398, 1982.
64. Zimmer HG. Normalization of Depressed Heart Function in Rats by Ribose. Science. 1983; 220: 81-82.
65. Zimmer HG, Ibel H. Effects of Ribose on Cardiac Metabolism and Function in Isoproterenol-Treated Rats. Am J Physiol. 1983; 245: H880-H886.
66. Zimmer HG, Ibel H. Ribose Accelerates the Repletion of the ATP Pool During Recovery from Reversible Ischemia of the Rat Myocardium. J Mol Cell Cardiol. 1984; 16: 863-866.
67. Zimmer HG, Ibel H, Stseinkopff G. Ribose Prevents the Propranolol-Induced Reduction of Myocardial Adenine Nucleotide Biosynthesis. Adv Exp Med Biol. 1984; 165(Pt B): 477-481.
68. Zimmer HG, Ibel H, Suchner U. Ribose Intervention in the Cardiac Pentose Phosphate Pathway is Not Species-Specific. Science. 1984; 223: 712-714.
69. Zimmer H-G, W Zierhut, G Marschner. Combination of ribose with calcium antagonist and beta-blocker treatment in closed-chest rats. J Mol Cell Cardiol 19:635-639, 1987.
70. Zimmer H-G, PA Martius, G Marschner. Myocardial infarction in rats: Effects of metabolic and pharmacologic interventions. Bas Res Cardiol 84:332-343, 1989.
71. Zimmer H-G. Regulation of and Intervention into the Oxidative Pentose Phosphate Pathway and Adenine Nucleotide Metabolism in the Heart. Mol Cell Biochem 160-161: 101-109, 1996.
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