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Eniva


Flex® (U.S. formulation)

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Scientific Reference>

Promoting Healthy Joints

Eniva Flex® provides powerful ingredients shown to support cartilage and connective tissue health, joint mobility, and address the discomfort associated with a lifetime of activity.* Generous amounts of Glucosamine, Chondroitin, MSM, Vitamin C, Vitamin B5, Vitamin B6, and Type II Collagen promote healthy joint structure and fluidity, while Phellodendron Amurense Bark Extract specifically addresses joint discomfort.*

  • Glucosamine is an important building block needed by the body to manufacture specialized components of cartilage called glycosaminoglycans.*
  • MSM contributes sulfur for protein synthesis and enzyme
    function to support tendons and cartilage.*
  • Chondroitin is a major constituent of cartilage, providing
    structure, holding water and nutrients, and allowing other
    nutrients to move through cartilage.*

The Eniva Flex active ingredients work in synergy to create a safe and natural combination to help you stay active and healthy.*

Flex Helps to Support:

  • Cartilage Health*
  • Synovium Health*
  • Joint Mobility*
  • Joint Comfort*

Flex (Citrus Flavor)
Suggested Retail: $29.95
32 oz. - ID 11000

Flex (Citrus Flavor-No Sucralose)
Suggested Retail: $29.95
32 oz. - ID 11012

Supplement Facts
Serving Size: 1 Fluid Ounce
Servings Per Container: 32
 
Amount Per Serving
% Daily Value
Vitamin C
120 mg
200%
Vitamin B6
3 mg
150%
Pantothenic Acid (Vitamin B5)
15 mg
150%
Glucosamine
2000 mg
MSM
500 mg
Chondroitin
150 mg
Type II Collagen
50 mg
† Daily Value not established.

Ingredients: Purified water, glucosamine HCl and/or glucosamine sulfate (from shellfish sources), methyl-sulfonyl-methane (MSM), chondroitin sulfate (from bovine sources), natural flavors, ascorbic acid, citric acid, type II collagen (from poultry sources), sucralose, sorbic and/or benzoic acid(s) (protect freshness), d-calcium pantothenate, pyridoxine HCl, phellodendron amurense bark extract.

Adult Directions: 1 ounce daily (2 tablespoons)
Recommended: 1 tablespoon in the morning, 1 tablespoon in the evening

Eniva Flex should be taken twice daily on an empty stomach. One of the key ingredients in Eniva Flex, a plant extract derived from Phellodendron Amurense Bark, may have decreased absorption when taken with food.

Bio-Available Properties
Due to the instant bio-available properties of this product, maximum absorption is achieved.

Eniva Flex utilizes Eniva's proprietary aqueous delivery system to provide enhanced bio-availability. The water used in this product has been enhanced with Structured Water Technology.

No Stimulants, No Artificial Colors, No Artificial Flavors.

Shake well before using. Refrigerate after opening.

Caution: Do not consume if tamper resistant seal is broken or missing. Keep cap tightly closed and out of reach of children. Not intended for children under 14 years of age. First consult your physician before starting this or any new mineral or nutrient supplement program. Discontinue use and consult your doctor if gastrointestinal problems occur.

Founded in Science

The ingredients and dosages used in the creation of Flex were based on clinical research studies. This synergistic blend is designed to create an environment within the body to help promote joint health and comfort.* The generous amounts of glucosamine, MSM, vitamin B5, and vitamin B6 promote healthy joint structure and fluidity, while phellodendron amurense bark extract specifically addresses joint discomfort.* The proprietary aqueous delivery system used to administer Flex provides increased absorption for maximum effectiveness.

Bio-Available Nutrients:

  • Vitamin B6
  • Pantothenic Acid (Vitamin B5)
  • Glucosamine Sulfate
  • Methyl-sulfonyl-methane (MSM)
  • Phellodendron Amurense
  • The Science Behind Body Support Flex
  • Vitamin B5 and B6

The Science Behind Body Support Flex

These B vitamins have been indicated in research trials as possibly playing a role in the promotion of joint health.* Specifically, vitamin B6 has been shown in research to help promote the health of the synovium, a sheath of tissue that surrounds tendons at joints.* It is also essential to the maintenance of hyaluronic acid, the lubricant inside of joints, especially the wrist.* In addition, vitamin B6 helps to stimulate the body’s production of cortisone, a natural substance that can impact the effects of swelling.*

Glucosamine is formed when glucose combines with an amino acid. It is a building block for cartilage. Glucosamine sulfate is a form of glucosamine that has some extremely beneficial implications, especially when used to promote the health of connective tissue.* Glucosamine sulfate is a small and simple molecular building block used for building cartilage and lubricating joints.

Glucosamine Sulfate

According to convincing research, glucosamine sulfate plays a role in body repair as well as cartilage building.* By providing joints with the essential raw materials, glucosamine sulfate can help promote cartilage health.* Research shows that it is absorbed into the body much more effectively than other "joint healers." Due to their small size, its molecules are absorbed at a rate of 98%. When comparing the mere 13% absorption rate of chondroitin sulfate, one can understand why glucosamine sulfate works so well. By stimulating the production of additional synovial fluid, studies show that glucosamine sulfate helps keep joints in the body functioning smoothly.*

Most studies show that supplementing a balanced diet with 500 milligrams three times a day is very effective. A daily serving of Flex provides a generous 2 grams of glucosamine sulfate. There have been no reported cases of toxicity associated with proper dosages of glucosamine sulfate.

Methyl-Sulfonyl-Methane (MSM)

Methyl-Sulfonyl-Methane (MSM) is organic sulfur. It is found in the fluid and tissues of all living organisms. It is also present in a variety of raw foods but is easily lost during moderate food processing. MSM is drastically depleted in foods that have been stored during shipping, refrigerated, or cooked. MSM bonds with moisture and is carried away when dehydration occurs.

In the body, MSM is used to repair damaged cells and to promote growth of healthy new cells.* MSM also makes cell walls more permeable, allowing waste materials to pass through them.*

MSM is an important cell builder and binder of soft tissues in the body. Sulfur has a vital relationship to protein and is found in essential amino acids such as methionine and cystine. It is necessary for collagen synthesis, a vital component in both the skin and the bones, where it knits the minerals together and gives flexibility to them.* It is also important in carbohydrate metabolism.

Phellodendron Amurense Bark Extract

Phellodendron amurense bark extract is derived from a common North American deciduous tree. This extract has been indicated to possess properties that may impact redness, swelling, and heat in joint structures.* This characteristic is in relation to a specific enzyme in the body.

Cyclooxygenase (COX)

Cyclooxygenase (COX) is an enzyme naturally present in our bodies. Scientists have discovered there are two forms of the COX enzyme:

COX-1 is produced widely throughout the body and is involved in the regulation of day-to-day cellular and metabolic activities, such as maintaining stomach lining integrity, regulating blood flow within the kidneys, and balancing platelet function. COX-1 is always present in the body and should not be inhibited.

COX-2 is an enzyme that is necessary for inducing pain. Ideally, the COX-2 enzyme is present in our bodies on a limited basis; however, factors such as diet, trauma, and injury can influence COX-2 production. When COX-2 is produced on a continual basis, constant pain ensues. Therefore, inhibiting COX-2 is an option for muscle and joint discomfort management.*

Phellodendron amurense bark extract has been indicated in research trials to specifically inhibit the action of COX-2.* Phellodendron amurense bark extract may have a large impact on body processes involved in how we experience discomfort.*

* This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Scientific References

Hsu and Associates. Oriental Materia Medica. Keats Publishing, Inc. 1986.

Ikuta and Nakamura. Canthin-6 one from the roots of Phellodenderon amurense. Planta Med. 1995, 61.

Sufka K. Anti-inflammatory/Analgesic animal model (series of three studies). University of Mississippi. May-Sept 2000 (unpublished).

Patterson D. An acute oral toxicity study in rats with SAC
1-0004X. Final Report. Springborn Laboratories, Inc. Ohio Research Center. Oct. 2000. 1-21.

Dupuis P. Study of the effects of NPS0029 (NextrutineTM) on various human cyclooxygenase activities. Cerep Laboratories, France (unpublished).

Dennis and Company Research. Anti-inflammatory Dietary Supplement HUT: Open Human clinical trial evaluating the efficacy and safety of NexrutineTM Sept 2000 (unpublished).

Bhide MB et al. Absorption, distribution and excretion of berberine. Ind Jour Med Res 1969; 57 (11).

Zeng X. HPLC determination of berberine in plasma of patients with ischemic heart failure. Chormatographia 1998; 48(7/8).

Ckless K et al. Inhibition of in vitro lymphocyte transformation by the isoquinoline alkaloid berberine. J Pharm Pharacol 1995 Dec, 47(12A): 1029-31.

Fukuda K et al. Inhibition of berberine of cyclooxygenase-2 transcriptional activity in human colon cancer cells. J Ethnopharmacol 1999 Aug, 66(2): 227-33.

Yasukawa K et al. Relative inhibitory activity of berberine type alkaloids against 12-O-tetradecanoylphorbo-13-acetate induced inflammation in mice. Chem Pharm Bull (Tokyo) 19991 Jun, 39(6): 1462-5.

Qiu, G.X., et al., Efficacy and safety of glucosamine sulfate versus ibuprofen in patients with knee osteoarthritis. Arzneim.-Forsch./Drug Res., 1998. 48(5): 469-474.

Drovanti, A., A.A. Bignamini, and A.L. Rovati, Therapeutic activity of oral glucosamine sulfate in osteoarthrosis: A placebo-controlled double blind investigation. Clinical Therapeutics, 1980. 3(4): 260-272.

Muller-Fassbender, H., et al., Glucosamine suflate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis and Cartilage, 1994. 2: 61-69.

D'Ambrosio, E., et al., Glucosamine sulphate: A controlled clinical investigation in arthrosis. Pharmatherapeutica, 1981. 2(8): 504-508.

Noack, W., et al., Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis and Cartilage, 1994. 2: 51-59.

Pujalte, J.M., E.P. Llavore, and F.R. Ylescupidez, Double-blind clincial evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Current Medical Research and Opinion, 1980. 7(2): 110-114.

da Camara CC, Dowless GV. Glucosamine sulfate for osteoarthritis. Ann Pharmacother. May1998;32(5):580-7.

Reginster et al. A randomized controlled clinical trial of glucosamine sulfate in osteoarthritis. Lancet. 2001. Vol 357: 251-56.

McCarty MF. Enhanced synovial production of hyaluronic acid may explain rapid clinical response to high-dose glucosamine in osteoarthritis. Med Hypotheses. Jun1998;50(6): 507-10.

Barton-Wright EC and WA Elliot. The pantothenic acidmetabolism of rheumatoid arthritis. Lancet. Vol. 2. 1963. 862-863.

Ellis JM and K Folkers. Clinical aspects of treatment of Carpal Tunnel Syndrome with Vitamin B6. Annals of the New York Academy of Sciences. vol 585. 1990. 302-320.

Folkers K, Ellis J, Watanabe T, Saji S, and M. Kaji. Biochemical evidence for a deficiency of Vitamin B6 in the Carpal Tunnel Syndrome based on a cross-over clinical study. Proceedings of the National Academy of Sciences. 1987. 3410-3412.

Ellis J. Vitamin B6 in the treatment of Carpal Tunnel and Shoulder-Hand syndromes. Journal of applied Nutriton. Vol 24. 1972. 75-76.

Ellis J. and J Presley. Vitamin B6: The Doctor’s Report. New York. Harper and Row. 1973. 57-73.

Lawrence R, Sanchez D, Grosman M. Lignisul MSM (methylsulfonylmethane) in the treatment of acute athletic injuries. Greenville, PA. 1999.

Lawrence RM. Methylsulfonylmethane (MSM): A double-blind study of its use in Degenerative Arthritis. International Journal of Anti-Aging Medicine, 1998 I(I); 50.

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